New publications from Bind explore the hurdles and solutions for drugging disordered proteins

30% of the human proteome is intrinsically disordered. Almost none of it is considered druggable. That is one of the largest unmet opportunities in medicine. Bind has recently published two papers setting out exactly why disordered proteins have resisted drug discovery for so long.

The barriers are real: no stable binding pockets, no scalable measurement tools, and no training data for AI-driven drug discovery. Bind Research exists to close all three gaps simultaneously.

Our white paper lays out how we are building the organisational infrastructure, measurement platforms and open datasets to enable drug discovery for IDPs.

Our perspective article in Current Opinion in Structural Biology sets out the scientific case in further detail. The field has been asking whether IDPs can be made widely druggable. We believe the answer is ‘YES!’, and our mission is to provide the tools and platforms to enable scientists across the world to prove it.

None of this would be possible without the vision and support of our funders and collaborators, to whom we say a huge thank-you!

White paper: https://zenodo.org/records/19057074
Current Opinion article: https://www.sciencedirect.com/science/article/pii/S0959440X26000187