What is an FRO?
A Focused Research Organisation (FRO) is an independent, not-for-profit startup-inspired entity dedicated to solving a scientific challenge and providing public goods (Marblestone et al., Nature, 2022).
FAQs
How can I learn more about starting an FRO?
Check out these resources:
Why can’t this be done in a university setting?
Academic expectations (publishing, grant acquisition, teaching) often prevent large-scale, team projects with high engineering scope from taking shape.
Also, this work sits between basic and applied science, making it difficult to fund via traditional grants.
Targeting many diverse disordered biomolecules and obtaining mechanistic insight for these interactions is generally not possible in academic settings. For these reasons, an FRO is the ideal structure for this project.
Why doesn’t industry do this?
We will create a large, publicly-available dataset for the benefit of the UK R&D ecosystem. Pharmaceutical companies and start-ups are disincentivised from sharing their tools, hits, and understanding of general binding mechanisms, even though doing so could dramatically accelerate drug discovery and improve societal health.
Can we help find new treatments for cancer?
Intrinsic protein disorder is prevalent in cancer, with many oncogenic proteins exhibiting disordered regions that facilitate complex signalling and regulatory mechanisms.
This intrinsic disorder in proteins often contributes to the molecular heterogeneity and adaptability of cancer cells, making them more resilient to treatments. Bind will have a strong focus on disordered proteins involved in various cancers.
Can we learn more about and improve existing therapeutics?
A highly general platform designed to screen for small molecule binders of disordered proteins could significantly enhance our understanding of the side effects and toxicity associated with existing drugs.
By mapping the interactions between small molecules and a wide array of disordered proteins, we can identify off-target effects that contribute to adverse reactions, thereby illuminating the complex network interactions within biological systems.
Such comprehensive profiling would facilitate a more holistic approach to drug safety assessment, enabling the prediction and mitigation of side effects through an integrated view of drug action and cellular response pathways.
What can we learn about fundamental biology from Bind’s work?
Interactions with proteins underpin vital biological processes across biology. Approximately one-third of all eukaryotic proteins contain some degree of disorder, and early evidence suggests that these regions can indeed interact with small molecules.
Nevertheless, there is currently a major technological gap, as we lack methodologies for biomolecular characterisation of the elusive interactions between disordered proteins and small molecules. Bind will develop cutting-edge biophysical methods to allow scientists to probe these highly dynamic interactions. For example, this work will allow us to uncover basic mechanisms of how metabolites and other small molecules interact with and alter the structures, functions, and stabilities of disordered proteins.
Why will Bind be protecting IP?
Development of potential drug molecules through to the therapy that can be administered to patients can cost over billions, and hence any company looking to take on this challenge requires assurances that development costs can be recovered once approved for clinical use.
This happens through patent protection, and allows the company to have a limited-time monopoly on the production and sale of a certain drug.
Due to the relative ease of manufacturing a drug compared to research and development of it, not having a patenting system like this in place would disincentivise industry from developing new medicines.
To ensure Bind’s findings can emerge into novel drugs, we need to protect our small-molecule hits and exclusively license this information to ensure maximum translational impact.
As a non-profit organisation, any revenue generated by Bind will be reinvested into the organisation to accelerate achieving our mission.
Why can’t you just dock to AlphaFold structures?
AlphaFold2 and AlphaFold3 were trained on the Protein Data Bank, a database of protein structures. Many protein structures in this database either do not have disordered regions (they were removed for X-ray crystallisation) or could not be resolved (e.g., in cryo-EM structures) due to their highly dynamic nature.
AlphaFold2 confidence scores are a good predictor of whether a given region is disordered (low scores correlate with disorder), but they cannot provide much information beyond this, particularly in the context of small-molecule interactions (Figure 1).
Figure 1: AlphaFold2 (Jumper et al., Nature, 2021) predicted structures of disordered proteins involved in various diseases. Yellow and orange regions correspond to low per-residue confidence scores which strongly correlate with disordered regions.
Are disordered proteins really disordered in cells?
Recent experimental work has demonstrated that while the cellular environment can tune structural ensembles of disordered proteins, disordered proteins’ lack of secondary structure persists in the cell (Moses et al., Nat. Struct. Mol. Biol., 2024, Theillet et al., Nature, 2016).
How can I apply to work at Bind Research?
We advertise open positions on our website and through relevant academic and industry channels. If you are interested in joining the team, keep an eye on our careers page or reach out to us with your CV and a short introduction.
Bind Research is always interested in hearing from talented scientists, engineers, and research professionals who are passionate about advancing our understanding of intrinsically disordered proteins and their role in disease.
Open roles will typically be listed on our website, along with details about the role, required experience, and how to apply. Even if there are no current openings that match your profile, we welcome speculative enquiries from individuals who feel their skills align with our mission.
When reaching out, it’s helpful to include a CV and a brief overview of your research background or relevant experience, along with a note about the type of role you would be interested in.
What kinds of roles are available at Bind Research?
Our team brings together scientists, engineers, and operational specialists working across experimental biology, computational methods, and research infrastructure.
Bind Research is a multidisciplinary organisation. Our work involves a combination of experimental science, computational modelling, and technical platform development.
Roles at Bind may include positions in areas such as:
-
Molecular and structural biology
-
Computational biology and modelling
-
Data science and machine learning
-
Software and platform engineering
-
Research operations and programme management
We aim to build collaborative teams that combine different scientific and technical perspectives. As our research programmes grow, we expect new opportunities to arise across these areas.
Do you offer internships or early-career opportunities?
We aim to support the development of early-career researchers and may offer internships or other short-term opportunities as our programmes expand.
Supporting early-career researchers is an important part of building the long-term scientific community around intrinsically disordered proteins.
While internship and placement opportunities may vary depending on current research activity and team capacity, we expect to offer opportunities for students and early-career researchers to gain experience in areas such as computational biology, data analysis, and experimental research.
If you are interested in potential placements or internships, we encourage you to get in touch with a short summary of your background and research interests.